Actualités

Communiqué de presse - "Un nouveau pas en hadronthérapie"

Des travaux dirigés par Yolanda Prezado, responsable de l'équipe NARA du laboratoire Imagerie et modélisation en neurobiologie et cancérologie (IMNC, CNRS / Université Paris-Sud / Université Paris-Diderot) ont permis de démontrer l’efficacité d’une nouvelle technique d’hadronthérapie par minifaisceaux de protons. Cette nouvelle méthode permet entre autre une plus grande préservation des tissus sains par rapport aux traitements conventionnels. Ces résultats ont été publiés le 31 octobre dernier dans la revue Scientific reports et font l'objet d'un communiqué de presse.

Prix de la recherche en technologie chirurgicale innovante

Les travaux de recherche menés par Darine Abi Haidar sur le développement d'un outil laser optique en endourologie (étude ARALUB et MEUC, en collaboration avec avec l'Hôpital Tenon et l'UPMC) viennent d'être récompensés par l'Académie Nationale de Chirurgie ! En effet, le projet avait été nominé par l'Académie Nationale de Chirurgie pour le prix de la recherche en technologie chirurgicale innovante.

La remise officielle du prix aura lieu dans le grand amphithéâtre de l'Académie Nationale de Médecine le 10 Janvier 2018.

Lumière sur les cellules tumorales

Comment un neurochirurgien peut-il être sûr qu'il a bien enlevé toute la tumeur cérébrale de son patient, tout en préservant les tissus sains, lorsqu'il opère ? Pour l'y aider, des chercheurs et médecins collaborent pour mettre au point une caméra capable de distinguer avec fiabilité pendant l'opération, les cellules saines des cellules malades. Pour cela, elle va analyser la fluorescence naturellement émise par les tissus, riche en informations, et comparer le résultat à une banque de données, avant de donner son verdict final : tissu sain ou tissu tumoral. Pour constituer cette base de données, les chercheurs viennent, entre autres, au synchrotron SOLEIL, sur la ligne DISCO, pour établir les caractéristiques des différents types de cellules dans l'ultraviolet.

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Publications récentes

Gamma-background rejection method for a dual scintillator positron probe dedicated to radio-guided surgery

M.-A. Verdier, S. Spadola, L. Pinot, C. Esnault, Y. Charon, M.-A. Duval, L. Ménard


We developed a positron intraoperative probe with high sensitivity dedicated to real-time assessment of the resection margins of tumors and control of the surgical cavity. Its main limitation comes from the annihilation photon background generated by distal non-specific radiotracer uptakes. This study is a proof of concept for a dual-scintillator intraoperative probe with background subtraction capability. It associates a highly p-terphenyl ββ-sensitive scintillator and a highly γγ-sensitive LYSO:Ce.

Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies: a proof of concept

Y. Prezado, M. Dos Santos, W. Gonzalez, G. Jouvion, C. Guardiola, S. Heinrich, D. Labiod, M. Juchaux, L. Jourdain, C. Sebrie and F. Pouzoulet


Minibeam radiation therapy (MBRT) is an innovative synchrotron radiotherapy technique able to shift the normal tissue complication probability curves to significantly higher doses. However, its exploration was hindered due to the limited and expensive beamtime at synchrotrons. The aim of this work was to develop a cost-effective equipment to perform systematic radiobiological studies in view of MBRT. Tumor control for various tumor entities will be addressable as well as studies to unravel the distinct biological mechanisms involved in

Proton minibeam radiation therapy spares normal rat brain: Long-Term Clinical, Radiological and Histopathological Analysis

Y. Prezado, G. Jouvion, D. Hardy, A. Patriarca, C. Nauraye, J. Bergs, W. González, C. Guardiola, M. Juchaux, D. Labiod, R. Dendale, L. Jourdain, C. Sebrie and F. Pouzoulet


Proton minibeam radiation therapy (pMBRT) is a novel strategy for minimizing normal tissue damage resulting from radiotherapy treatments. This strategy partners the inherent advantages of protons for radiotherapy with the gain in normal tissue preservation observed upon irradiation with narrow, spatially fractionated beams. In this study, whole brains (excluding the olfactory bulb) of Fischer 344 rats (n = 16) were irradiated at the Orsay Proton Therapy Center. Half of the animals received standard proton irradiation, while the other half were

Optical properties, spectral, and lifetime measurements of central nervous system tumors in humans

F. Poulon, H. Mehidine, M. Juchaux, P. Varlet, B. Devaux, J. Pallud and D. Abi Haidar


A key challenge of central nervous system tumor surgery is to discriminate between brain regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of autofluorescence could potentially be an efficient way to provide reliable information for these regions, we found little information on this subject, and thus we conducted studies of brain tissue optical properties. This particular study focuses on the different optical quantitative responses of human central nervous system tumors and their corresponding controls.

Experimental assessment of the safety and potential efficacy of high irradiance photostimulation of brain tissues

S. Senova, I. Scisniak, C.-C Chiang, I. Doignon, S. Palfi, A. Chaillet, C. Martin and F. Pain


Optogenetics is widely used in fundamental neuroscience. Its potential clinical translation for brain neuromodulation requires a careful assessment of the safety and efficacy of repeated, sustained optical stimulation of large volumes of brain tissues. This study was performed in rats and not in non-human primates for ethical reasons. We studied the spatial distribution of light, potential damage, and non-physiological effects in vivo, in anesthetized rat brains, on large brain volumes, following repeated high irradiance

Endogenous fluorescence analysis: preliminary study revealing the potential of this non-invasive method to study mummified samples

M. Zanello, J. Pallud, S. Jacqueline, A. Augias, P. Varlet, B. Devaux, O. Nielsen, D. Abi Haidar and P. Charlier


Autofluorescence analysis allows new insights on human tissue without any dye in a non-invasive way and therefore seems well suited to study historical samples. An optical set-up recorded emitted autofluorescence in 1/spectral and 2/lifetime domains from different samples’ regions of interest. The studied samples were: a mummified right hand; bog body (Tollund Man) feet, and a Caucasian male hand (control sample). Spectral analysis revealed that mummified hand exhibited broad autofluorescence spectra whereas Tollund Man feet exhibited a weak single peak with

Simulation of nanoparticle-mediated near-infrared thermal therapy using GATE

Vesna Cuplov, Frédéric Pain and Sébastien Jan


Application of nanotechnology for biomedicine in cancer therapy allows for direct delivery of anticancer agents to tumors. An example of such therapies is the nanoparticle-mediated near-infrared hyperthermia treatment. In order to investigate the influence of nanoparticle properties on the spatial distribution of heat in the tumor and healthy tissues, accurate simulations are required. The Geant4 Application for Emission Tomography (GATE) open-source simulation platform, based on the Geant4 toolkit, is widely used by the research community involved in

Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls

M. Zanello, F. Poulon, J. Pallud, P. Varlet, H. Hamzeh, G. Abi Lahoud. F. Andreiuolo, A. Ibrahim, M. Pages, F. Chretien, F. Di Rocco, E. Dezamis, F. Nataf, B. Turak, B. Devaux and Darine Abi Haidar


Delineating tumor margins as accurately as possible is of primordial importance in surgical oncology: extent of resection is associated with survival but respect of healthy surrounding tissue is necessary for preserved quality of life. The real-time analysis of the endogeneous fluorescence signal of brain tissues is a promising tool for defining margins of brain tumors. The present study aims to demonstrate the feasibility of multimodal optical analysis to discriminate fresh samples of gliomas, metastases and meningiomas from their appropriate controls.

Design optimization and performances of an intraoperative positron imaging probe for radioguided cancer surgery

S. Spadola, M.-A. Verdier, L. Pinot, C. Esnault, N. Dinu, Y. Charon, M.-A. Duval and L. Ménard


Extent and accuracy of surgical resection is a crucial step in operable tumor therapy. Emergence of promising specific tumor-seeking agents labeled with positron emitters is giving rise to a renewed interest for radioguided surgery using beta probes. Beta detection, due to the particle short range, allows a more sensitive and accurate tumor localization compared to gamma radiotracers.

Optical properties of mice skull bone in the 455-705 nm range

Soleimanzad H, Gurden H, and Pain F


The activity of cell populations and networks is commonly recorded in vivo in rodents  with wide field optical imaging techniques such as intrinsic optical imaging, fluorescence imaging or laser speckle imaging. These techniques were recently adapted to unrestrained mice carrying transcranial windows. Furthermore, optogenetics studies would benefit from optical stimulation through the skull without implanting an optical fiber, especially for longitudinal studies.

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